Neurobiology of Disease Enhanced Adult Neurogenesis and Angiogenesis and Altered Affective Behaviors in Mice Overexpressing Vascular Endothelial Growth Factor 120
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چکیده
Hiroshi Udo,1 Yuka Yoshida,1 Takako Kino,2 Koichiro Ohnuki,2 Wataru Mizunoya,3 Takao Mukuda,4 and Hiroyuki Sugiyama1 1Department of Biology, Faculty of Science, and 3Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 8128581, Japan, 2 Evaluation and Management Department, User Science Institute, Kyushu University, Fukuoka 815-8540, Japan, and 4Department of Human Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Hiroshima 739-8521, Japan
منابع مشابه
Enhanced adult neurogenesis and angiogenesis and altered affective behaviors in mice overexpressing vascular endothelial growth factor 120.
Vascular endothelial growth factor (VEGF) is implicated as a molecular mediator for adult neurogenesis and behavioral effects of antidepressant drugs. However, these potential roles of VEGF in the CNS have not been clarified in model animals. Here we have created transgenic mice overexpressing a short active variant of VEGF-A (VEGF120) in forebrain. Expression of VEGF120 significantly enhanced ...
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تاریخ انتشار 2008